DEA Form 106: Reporting the Loss of Controlled Substances
Why DEA Form 106 Reporting Matters for ASCs and Healthcare Facilities
In the high-stakes environment of Ambulatory Surgery Centers (ASCs) and healthcare facilities, controlled substances play a vital role in patient care — but they also require strict accountability.
When controlled substances go missing due to theft, diversion, or accidental loss, facilities are required by law to act quickly. Submitting DEA Form 106 is not just a compliance measure; it’s essential to protect patients, staff, and your organization’s license.
Understanding DEA Reporting Requirements
As a DEA registrant, your facility must report any significant loss or theft of controlled substances within one business day of discovery.
Your Legal Obligations Include:
Submitting DEA Form 106 (Report of Theft or Loss of Controlled Substances)
Maintaining records and investigation files for at least two years
Documenting all corrective actions and follow-up measures
The DEA does not define a specific “significant” quantity, but factors to consider include:
The actual amount missing
Risk to patient care or public safety
Likelihood of diversion
Local theft or diversion trends
For official guidance, visit the DEA Diversion Control Division website.
Step-by-Step Guide: How to Complete DEA Form 106
Step 1: Immediate Notification
Contact your local DEA field office immediately after identifying a loss.
Record the date, time, and agent name you spoke with for your records.
Step 2: Access the Form
Go to the DEA Diversion Control Division Portal
Select “Report Theft/Loss of Controlled Substances” under Resources.
Log in using your DEA registration number and credentials.
Step 3: Complete All Required Sections
Provide detailed information on:
Your facility and DEA registration
Circumstances of the loss (e.g., theft, breakage, in-transit)
Drug name, strength, and quantity
Law enforcement notifications
Corrective actions implemented
Step 4: Submit and Maintain Records
Submit DEA Form 106 electronically
Print and store a copy in your compliance records
Document corrective actions and investigations internally
Beyond Reporting: How to Prevent Controlled Substance Losses
While knowing how to file DEA Form 106 is crucial, prevention is even more important.
1. Smarter Inventory Management
Use digital inventory tracking systems for real-time visibility.
Conduct weekly audits of high-risk drugs (e.g., fentanyl, hydromorphone).
Implement a witness verification system for all waste documentation.
Investigate discrepancies immediately, not at the end of shifts.
2. Strengthen Physical and Digital Security
Install cameras covering storage and disposal areas.
Employ waste disposal systems that make drugs unusable instantly.
Schedule routine security assessments to identify vulnerabilities.
3. Create a Culture of Awareness
Train staff to spot signs of diversion or substance use disorder.
Promote judgment-free reporting for suspicious behavior.
Discuss new diversion trends during team meetings.
4. Maintain Strong Documentation Practices
Keep comprehensive transfer logs and witness signatures.
Store digital audit trails for all drug transactions.
Use electronic systems that flag unusual activity or discrepancies.
Supporting Your Team and Staying Prepared
Filing DEA Form 106 can be stressful — especially if diversion by a colleague is suspected. That’s why proactive support and training matter.
MedServe provides:
Documentation templates for internal investigations
ASC staff training on diversion prevention and reporting
Compliance consulting to ensure DEA alignment
Security enhancement services tailored to healthcare facilities
Conclusion: Protecting Your Facility with DEA Form 106 Compliance
Prompt, accurate submission of DEA Form 106 safeguards your patients, staff, and license — but real protection starts with strong prevention systems.
By pairing DEA compliance with robust controlled substance tracking and team education, ASCs can minimize risks and uphold the highest standards of safety and integrity.
Ensure your facility stays compliant and secure. Connect with MedServe today for expert guidance on controlled substance management and DEA requirements.
